Microsoft Research launches Quine, an AI world model built for biological discovery

In short: Microsoft Research has unveiled Quine, a research system combining a multimodal 'world model' of biology with an interactive harness linking AI models, scientific literature, lab tools, and researchers. Built jointly across data types such as genomics, proteins, chemistry, RNA/cell state, and bioimaging, the model aims to predict how biological systems respond to interventions before costly lab experiments are run. Working with the Broad Institute of MIT and Harvard, Microsoft used Quine to rank thousands of compounds for their potential to shift pancreatic cancer cells between therapeutic states, and the top-ranked candidates were validated in wet-lab assays within a single weekend. Microsoft is now opening a 'Quine Fellows' program to give selected scientists early access, while cautioning that the system is experimental, research-only, and not intended for clinical use.

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